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. Author manuscript; available in PMC: 2016 Mar 5.
Published in final edited form as: Microcirculation. 2015 Jan;22(1):44–53. doi: 10.1111/micc.12164

Figure 2.

Figure 2

The effects of nitric oxide synthase (NOS) and cyclooxygenase (COX)inhibition on flow-induced dilation (FID) in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) arterioles. NOS inhibition with L-NAME, significantly reduced FID in SAT (A). Indomethacin (INDO) reduced FID in SAT, but had no additional effect in the presence of L-NAME (A). The presence of L-NAME or INDO had no effect on FID in VAT resistance arteries (B). However, the combination of L-NAME and INDO reduced dilation at higher flow rates in VAT vessels (B). There is a significant group by dose effect for flow (P=0.035) *p<0.001 baseline vs. inhibitors in SAT or VAT at each level of flow or ACh (n=17–21). PAP: papavarine (10−4 M)