Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 1;38:261–273. doi: 10.1007/s00281-015-0522-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 2 — Signals involved in early granuloma formation. Studies in zebrafish suggest that mycobacteria (red) inside infected macrophages (blue) secrete the ESAT6 virulence factor, which, in turn, induces nearby epithelial cells (brown) to secrete the matrix metalloproteinase Mmp9 that is thought to facilitate the migration of macrophages [55]. This matrix degradation pathway could act cooperatively with Cxcr3-Cxcl11 signaling between infected and uninfected macrophages promoting the chemoattraction of macrophages and their aggregation into initial granulomas [59]