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ER integrity is preserved in PAX4-overexpressing islets. Two sets (upper and lower) of beta cell micrographs from islets isolated from PAX4 transgenic mice, treated with DOX or not treated, and challenged with 1 μmol/l thapsigargin or not challenged. Arrows indicate the RER. Inset is enlarged below each image. Scale bar, 0.5 μm. N, nucleus; V, insulin vesicles
