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. Author manuscript; available in PMC: 2017 Mar 3.
Published in final edited form as: Mol Cell. 2016 Mar 3;61(5):654–666. doi: 10.1016/j.molcel.2016.01.028

Figure 3.

Figure 3

Parkin-dependent mitophagy. In healthy mitochondria, the PINK1 kinase is constitutively degraded. A fall in mitochondrial membrane potential (Δψm) stabilizes PINK1 facilitating the recruitment of cytosolic Parkin to the mitochondrial outer membrane. Activation of Parkin results in the ubiquitinization (purple balls) of multiple outer mitochondrial membrane proteins (shown in green). Once ubiquinated, these proteins are recognized by specific mitophagy receptors such as optineurin (OPTN) and NDP52, which along with LC3, directs the phagophore to surround the damaged mitochondria allowing for its ultimate delivery to the lysosome for degradation via mitophagy.