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. Author manuscript; available in PMC: 2017 Jan 21.
Published in final edited form as: Cell Chem Biol. 2016 Jan 21;23(1):122–136. doi: 10.1016/j.chembiol.2015.12.003

Figure 2. General considerations for probe design.

Figure 2

A. Optical chemical probes consist of 3 main structural elements: the dye, linker, and recognition element. B. General model for affinity-based probes. The probe binds to targets such as receptors, ion channels and membranes with high affinity. C. General model for activity-based probes. These probes give off a fluorescent signal upon processing by enzymes such as proteases and peptidases.