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. 2016 Mar 5;16:186. doi: 10.1186/s12885-016-2211-7

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© Afasizheva et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — A375 and A375.S2 colonies show a differential response to drug treatment. Schematic showing the timing of drug administration for cells embedded in 3D soft agar with treatment commencing after colony formation. Growth of isogenic colonies in 3D soft-agar assays shows differential response to drug treatment. A375 colonies (Top panel) are largely insensitive to drug treatment, whereas A375.S2 (Bottom panel) cells form fewer colonies of smaller size as determined by diameter