Fig. 7.

Multiple alignments of the full-length coding sequences of major isoforms of waprin (cluster BC16, a representative clone JZ880126) from B. colombiensis with other homologous venom proteins. The alignment was generated with the ClustalW multiple sequence alignment program with manual adjustment and displayed with shaded boxes. The numbers in parenthesis are the NCBI accession numbers. Identical residues are marked in black. All cysteine residues (an asterisk above the sequences) are conserved. The bar (-) was introduced for optimal comparison. The inhibition loop is underlined. The sources of sequences are as follows: waprin [BAN89446.1] from Ovophis okinavensis, waprin-Phi1 [A7X4K1.1] from Philodryas olfersii, waprin-Rha1 [A7X4J4.1] from Rhabdophis tigrinus tigrinus, Nawaprin [P60589.1] from Naja nigricollis. The  % identities are shown in the figure