Table 4.

Effect of selected extracellular matrix components on dermal fibroblast functions

Extracellular Matrix Component	Fibroblast Proliferation	Fibroblast Migration	Collagen Production/Assembly	Myofibroblast Differentiation/Contraction	References
Collagen I	↓↑	↑	↑	↑	39, 40, 49, 50, 53
Collagen III	–	–	↑	↓	61, 62
Collagen IV	–	–	–	–	NA
Collagen V	↑	↑	↑	–	63, 64, 66,
Collagen VI	↑	↓↑	↑	–	154
Collagen VII	–	↑	↓	↓	75, 77
Collagen XIV	↓	–	↑	↓	78, 79
Fibrin	↑	↑	↑	↑	83, 85
Fibronectin	↑	↑	↑	↑	158
Vitronectin	↓	↑	–	↑	84, 88, 90
Elastin	↑	↑	↑	↓	91, 92, 93
Hyaluronan	↓↑	↑	↓↑	↓↑	158, 186
Dermatan sulfate	↑	↑	–	–	187
Chondroitin sulfate	↑	↑	–	–	188
Decorin	↓	↓	↓	↓	115, 158
Versican	–	↓↑	↑	↑	184
Lumican	↓	–	↑	↑	121
Dermatopontin	–	↑	↑	↓	158
Osteopontin	↑	↑	↑	↑	127
SPARC	–	↓	↑	–	130
CCN2	↑	↑	↑	↓↑	134, 137, 140
Tenascin-C	↓	↓↑	↑	↑	144, 158, 159
Fibulin-5	↓↑	↓↑	↓↑	↑	145, 146

Up-arrows (↑) show an increase or improvement, down-arrows (↓) show a decrease or impairment, bidirectional arrows (↓↑) show no apparent effect, and dashes (–) indicate an unknown or unstudied effect.

(↑) Increased; (↓) Decreased; (↓↑) No effect; (–) Unknown effect.