Table 4.
Factors Associated With Enhanced Liver Fibrosis (ELF) Scores for 73 Women With Human Immunodeficiency Virus (HIV)/Hepatitis C Virus (HCV) Coinfection and 165 Women With HIV Monoinfection
| Factor | HIV/HCV Coinfection, Percentage Difference (95% CI) |
HIV Monoinfection, Percentage Difference (95% CI) |
||
|---|---|---|---|---|
| Unadjusted | Adjusted | Unadjusted | Adjusted | |
| Demographic factors | ||||
| Age (per decade) | 5 (1–8) | 4 (1–7) | 4 (2–7) | 4 (2–6) |
| Race/ethnicity (reference, white) | ||||
| Black | 2 (−4 to 8) | −2 (−7 to 2) | −1 (−5 to 3) | −2 (−6 to 2) |
| Hispanic | 10 (0–21) | 3 (−3 to 9) | 1 (−4 to 7) | 0 (−5 to 5) |
| Other | −8 (−13 to −3) | −3 (−11 to 5) | 3 (−4 to 9) | 5 (−1 to 12) |
| HOMA-IR score (per doubling) | 2 (1–4) | … | 1 (0–3) | … |
| IL-6 level (per doubling) | 3 (0–5) | … | 2 (1–10) | 1 (0–3) |
| HDL level (per doubling) | −8 (−12 to −4) | −4 (−7 to 0) | 0 (−3 to 4) | 0 (−3 to 3) |
| HIV-related factors | ||||
| HIV RNA level (> 50 vs ≤50 copies/mL) | 0 (−5 to 5) | … | 2 (−1 to 6) | … |
| Nadir CD4+ T-cell count (<200 vs >200 cells/mm3) | 5 (0–11) | 4 (0–7) | 5 (2–9) | 3 (0,–6) |
| Liver-related factors | ||||
| HCV RNA load (per doubling) | 0 (−1 to 1) | … | … | … |
| ALT level (per doubling) | 2 (−1 to 5) | … | 1 (−2 to 4) | … |
| AST level (per doubling) | 3 (0–6) | … | 4 (0–8) | … |
| Liver stiffness (per doubling) | 8 (6–10) | 7 (5–9) | 6 (2–10) | 5 (1–8) |
Data are from generalized linear regression analyses.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval; HDL, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; IL-6, interleukin 6.