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. 2015 Nov 26;213(7):1189–1197. doi: 10.1093/infdis/jiv570

Figure 2.

Figure 2.

Toll-interacting protein (TOLLIP) and interleukin 1 receptor antagonist (IL-1Ra) immunohistochemical findings. Skin biopsy specimens were obtained from lesions in individuals with leprosy and stained for TOLLIP and IL-1Ra. A and B, A skin biopsy specimen from a representative individual with 3+ TOLLIP and 3+ IL-1Ra staining (A) and 1+ TOLLIP and 1+ IL-1Ra staining (B). C, Plot of the IL-1Ra messenger RNA level, normalized to GAPDH, compared to the IL-1Ra immunohistochemical grade staining score (1+–3+). IL-Ra protein expression and mRNA expression were correlated by linear regression. *P = .0031. D, The TOLLIP mRNA level, normalized to GAPDH, was compared to the TOLLIP immunohistochemical grade staining score (1+–3+). TOLLIP protein expression and mRNA expression were correlated by linear regression. **P < .0001.