Table 6.

Multivariable Analyses Associating RBC Indices With HAND Among 862 Subjects Continuously Receiving HAART, With Use of Repeated Measures During Follow-up

Variable	All HAND, OR (95% CI)	P Value	MND, OR (95% CI)	P value	HAD, OR (95% CI)	P value
HANDb
MCV	1.02 (1.00–1.03)	<.05c	1.04 (1.01–1.07)	<.01c	1.06 (1.01–1.12)	.02c
MCH	1.05 (1.01–1.10)	.03c	1.14 (1.05–1.23)	<.01c	1.16 (1.01–1.34)	.04c

Abbreviations: CI, confidence interval; HAART, highly active antiretroviral therapy; HAD, human immunodeficiency virus (HIV)–associated dementia; HAND, HIV-associated neurocognitive disorder; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; MND, mild neurocognitive disorder; OR, odds ratio; RBC, red blood cell.

^a Regression models were adjusted for the baseline value of MCV (or MCH), age, sex, CD4⁺ T-cell nadir, zidovudine use, plasma HIV RNA concentration, Wide-Range Achievement Test III score (baseline), self-reported race/ethnicity, and non–HIV-related comorbid conditions (incidental or contributing to neurocognitive impairment).

^b HAND was defined according to Frascati criteria.

^c Significant difference (P < .05, from logistic regression analyses).