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. Author manuscript; available in PMC: 2016 Aug 18.
Published in final edited form as: Acc Chem Res. 2015 Aug 5;48(8):2462–2474. doi: 10.1021/acs.accounts.5b00265

Figure 1.

Figure 1

Cytochrome c oxidase reduces dioxygen via the proposed intermediates shown (top). This heme-a3/CuB binuclear active-site also functions in NO2−/NO(g) interconversion in a regulatory role modulating O2-balance (bottom).