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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Jan 7;50:95–104. doi: 10.1016/j.semcdb.2015.12.015

Figure 2. 7TMR/GPCR signal regulation.

Figure 2

A) Receptor desensitization. GRKs phosphorylate the C-terminal of activated GPCRs. Arrestin binds to the phosphorylated receptor that is then sterically blocked from interacting with cognate G protein. B) Receptor sequestration. Arrestin serve as an adaptor and recruit endocytic machinery proteins to mediate GPCR internalization into vesicles. GPCR internalization sequesters the activated receptors from further stimulation. C) Arrestin may dissociate or remain bound to the receptor in vesicle. Early dissociation of arrestin promotes receptor recycling. Failure of the arrestin-GPCR complex to dissociate marks that receptor for further processing that results in either receptor degradation or delayed receptor recycling.