Fig. 3.

Effects of adult beta cell-specific Bmal1 deletion on glucose tolerance in vivo following exposure to either chow or HFD. Graphs depicting sampled blood glucose and corresponding glucose AUC during 90 min i.p. glucose tolerance tests conducted at baseline and 2, 4, 6 and 8 weeks after tamoxifen in β-Bmal1^+/+ (white circles/bars), β-Bmal1^+/− (grey circles/bars) and β-Bmal1^−/− (black circles/bars) mice exposed to 8 weeks of (a, b) chow or (c, d) HFD. (a–d) Data expressed as mean ± SEM (n=5–7 per group). Statistical significance is denoted by *p<0.05, **p<0.01, ***p<0.001 and ****p<0.0001. Baseline data are common for chow and HFD groups