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. Author manuscript; available in PMC: 2017 Mar 4.
Published in final edited form as: Circ Res. 2016 Jan 11;118(5):786–797. doi: 10.1161/CIRCRESAHA.115.305298

Figure 6. Functional annotation reveals mechanisms linking differential methylation after ISO to cardiac phenotype.

Figure 6

Cardiac-specific pathways were examined for enrichment in differentially methylated genes using Ingenuity Pathway Analytics, revealing cardiac development to be physiological process most targeted by differential methylation after ISO. Interestingly, several known cardiac genes underwent altered regulation, allowing relationships amongst the signaling network to be mapped. Red nodes are differentially methylated only in BALB/cJ; green nodes only in BUB/BnJ; orange in both and white in neither. Solid lines indicated validated direct relationships; dashed lines, validated indirect interactions.