Table 2.
DNA fragments with altered CpG methylation in both strains
| Chromosome | Start | End | Diff. Met (BALB/cJ) |
Diff. Met (BUB/BnJ) |
Associated Gene |
|---|---|---|---|---|---|
| Up in both | |||||
| chr1 | 189873628 | 189873810 | 10.85% | 10.05% | Smyd2 (+48644), Ptpn14 (+145451) |
| chr2 | 27182325 | 27182514 | 11.71% | 10.49% | Dbh (+17186), Sardh (+64847) |
| chr4 | 134316356 | 134316481 | 13.37% | 16.03% | Slc30a2 (−26788), Trim63 (+1298) |
| chr7 | 128540107 | 128540257 | 13.72% | 15.52% | Inpp5f (−71178), Bag3 (+16599) |
| chr8 | 120582053 | 120582171 | 10.49% | 10.14% | Gins2 (+7192), Gse1 (+93665) |
| chr8 | 122238337 | 122238506 | 15.54% | 14.03% | Gm22 (−31148), Banp (+287877) |
| chr8 | 122238507 | 122238633 | 17.16% | 14.12% | Gm22 (−30999), Banp (+288026) |
| chr18 | 37842431 | 37842627 | 10.70% | 10.98% | Pcdhga11 (+22983), Diap1 (+92947) |
| chr18 | 84192436 | 84192578 | 10.18% | 14.11% | Zadh2 (+104349), Zfp407 (+396997) |
| Down in both | |||||
| chr1 | 89992857 | 89993101 | −17.99% | −17.27% | Gbx2 (−59689), Asb18 (+21598) |
| chr1 | 131010735 | 131010911 | −14.65% | −12.38% | Il19 (−71582), Il10 (−9022) |
| chr1 | 182108412 | 182108579 | −12.25% | −11.32% | Enah (−88515), Srp9 (−16255) |
| chr5 | 63936930 | 63937056 | −30.98% | −27.08% | Rell1 (+31912), 0610040J01Rik (+124498) |
| chr5 | 119680671 | 119680792 | −14.89% | −15.65% | Tbx5 (−153932), Tbx3 (+9713) |
| chr5 | 119841821 | 119842008 | −10.13% | −14.21% | Rbm19 (−274596), Tbx5 (+7251) |
| chr5 | 135621905 | 135622044 | −16.49% | −12.05% | Ccl24 (−48931), Rhbdd2 (−10644) |
| chr6 | 91965207 | 91965382 | −19.10% | −14.33% | Fgd5 (−21816), 4930590J08Rik (+50535) |
| chr7 | 25645126 | 25645303 | −10.19% | −10.14% | Bckdha (+13547), B3gnt8 (+17590) |
| chr8 | 83668524 | 83668653 | −12.78% | −12.31% | Ptger1 (+1725), Pkn1 (+25472) |
| chr10 | 66770619 | 66770763 | −17.70% | −11.02% | Reep3 (+326297) |
| chr10 | 68268862 | 68269022 | −10.68% | −11.80% | Arid5b (+9784), Rtkn2 (+289344) |
| chr11 | 106659519 | 106659639 | −10.27% | −11.17% | Tex2 (−46649), Pecam1 (+55680) |
| chr11 | 117353468 | 117353611 | −10.96% | −15.55% | Gm11733 (−130829), Sept9 (+153878) |
| chr13 | 44534613 | 44534790 | −14.24% | −16.57% | Jarid2 (−196570), Cd83 (+749594) |
| chr14 | 44865790 | 44865946 | −13.20% | −12.50% | Ptger2 (−122327), Ptgdr (−6493) |
| chr15 | 76188602 | 76188749 | −15.50% | −11.39% | BC024139 (−62133), Plec (+17646) |
| chr15 | 102106728 | 102106852 | −14.85% | −13.63% | Tenc1 (+3802), Spryd3 (+29444) |
| chr16 | 8562615 | 8562745 | −11.76% | −15.22% | Pmm2 (−74994), Abat (+49251) |
| chr16 | 37681813 | 37681987 | −11.87% | −12.73% | Fstl1 (−94973), Ndufb4 (−27447) |
| chr17 | 65744154 | 65744265 | −18.76% | −16.28% | Txndc2 (−102005), Rab31 (+28543) |
| chr19 | 5569310 | 5569437 | −14.86% | −16.70% | Rnaseh2c (−32500), Ap5b1 (+1299) |
Diff. Met: Difference of CpG methylation after ISO treatment.