Table 1.
Mean ± SD ammonia, CAR, and ALCAR levels and ACYLCAR/CAR ratio in patients with PHT (Group A) and in patients with VPA (Group B). Mean plasma VPA concentrations of patients in Group B are also shown.
| Ammonia ± SD (μg/dL) |
VPA ± SD (mg/L) |
CAR ± SD (μmol/L) |
ALCAR ± SD (μmol/L) |
ACYLCAR/CAR ± SD | |
|---|---|---|---|---|---|
| Group A | 61.7 ± 27.3 | 37.8 ± 8.6 | 11.5 ± 3.0 | 0.35 ± 0.15 | |
| Group B | 105.2 ± 57.2 | 39.8 ± 13.0 | 12.6 ± 5.5 | 0.45 ± 0.13 | |
| p value | 0.005 | NS | NS | 0.0005 | |
| Normal values in healthy individuals | 25–94 | 19–59 | >9.8 | 0.1–0.40 | |
| Group B | |||||
| With hyperammonemia | 140.0 ± 47.7a
p < 0.001 |
44.9 ± 29.8 | 34.9 ± 11.4 | 9.9 ± 3.0b
p < 0.025 |
0.44 ± 0.13c
p < 0.005 |
| Without hyperammonemia | 54.6 ± 19.7 | 30.1 ± 20.3 | 44.5 ± 10.3b
p < 0.025 |
17.4 ± 5.7a
p < 0.001 |
0.47 ± 0.11 |
a,b,cSignificantly different from the corresponding value in Group A.