Table 1.
Recent published clinical studies on CART cells specific for solid tumor antigens.
| Antigen | CAR | Gene transfer | Cancer | Case number | Clinical outcome | Time | Reference |
|---|---|---|---|---|---|---|---|
| HER2 | ScFv-CD28-CD3ζ | Retrovirus | HER2-positive sarcoma | 19 | 1 PR, 4 SD | 2015 | [15] |
| CEA | ScFv-CD28-CD3ζ | Retrovirus | CEA+ liver metastases | 8 | 1 SD, 5 DOD | 2015 | [17] |
| Mesothelin | ScFv-4-1BB-TCRζ | Electrotransfer | Mesothelioma | 2 | 1 PR, 1 SD | 2014 | [14] |
| Mesothelin | ScFv-4-1BB-TCRζ | Electrotransfer | Mesothelioma | 1 | 1 PR | 2013 | [16] |
| CAIX | ScFv-FcεRIγ | Retrovirus | CAIX+ metastatic RCC | 12 | NED | 2013 | [8] |
| GD2 | ScFv-CD3ζ | Retrovirus | Neuroblastoma | 19 | 3 CR, 1 PR | 2011 | [5] |
| ERBB2∗ | ScFv-CD28-4-1BB-CD3ζ | Gamma-retrovirus | Colon cancer | 1 | Dead | 2010 | [13] |
| GD2 | ScFv-CD3ζ | Retrovirus | Neuroblastoma | 11 | 1 CR, 2 SD, 2 tumor necrosis | 2008 | [12] |
| CD171 | ScFv-CD3ζ | Electrotransfer | Neuroblastoma | 10 | 1 PR | 2007 | [9] |
| FR | ScFv-FcεRIγ | Retrovirus | Ovarian cancer | 8 | NED | 2006 | [11] |
| CAIX | ScFv-FcεRIγ | Retrovirus | CAIX+ metastatic RCC | 3 | NED | 2006 | [7] |
CAIX: carboxy-anhydrase-IX; CEA: carcinoembryonic antigen; CR: complete response; DOD: dead of disease; FR: folate receptor; HER2: human epidermal growth factor receptor 2; NED: no evidence of disease; PR: partial response; RCC: renal cell carcinoma; ScFv: single chain fragment of variable region antibody; SD: stable disease.
∗HER2/neu.