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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Dec 23;1858(4):783–792. doi: 10.1016/j.bbamem.2015.12.024

Fig. 4.

Fig. 4

The effects of elevated [Na+]i or high [K+]e on Leu-209 mutant channel activity. (A) I–Vt relationships for oocytes expressing either wt (n = 5) or mutant Slo2.1 channels (L209A, n = 4; L209N, n = 4; L209E, n = 7). Currents were recorded immediately after impalement of an oocyte with 2M NaCl-containing electrodes (control), after maximum response to intracellular Na+ loading and again after addition of 1 mM NFA to the extracellular solution. (B) I–Vt relationships for wt (n = 6), L209A (n = 3), L209N (n = 4) and L209E (n = 7) Slo2.1 channels measured from oocytes bathed in K104 extracellular solution in the absence (control) and presence of 1 and 6 mM NFA. Error bars indicate ± S.E.