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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: J Immunol. 2016 Feb 3;196(6):2572–2582. doi: 10.4049/jimmunol.1501916

Figure 7. YY1 negatively regulates p53.

Figure 7

The abundance of transcripts encoding pro- and anti-apoptotic proteins, YY1, and p21 were analyzed in DP thymocytes of Yy1f/f (WT) and Yy1f/f Lck-Cre (Yy1Lck) mice, with normalization to Hprt (A) or Gapdh (B). Data represent the mean ± SEM of three WT and three Yy1Lck preparations, each from a different mouse. Statistical significance was evaluated by unpaired Student’s t-test with Holm-Sidak correction for multiple comparisons. Sorted DN3 thymocytes from WT or Yy1CD2 mice (C) or DP thymocytes from WT or Yy1Lck mice (D) were analyzed by western blot. Data are representative of three independent experiments. *P < 0.05, **P < 0.01, ****P < 0.0001.