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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: J Immunol. 2016 Feb 8;196(6):2646–2654. doi: 10.4049/jimmunol.1502294

Fig. 1. ADA injection of EAU-prone B6 mice on day 8 post-immunization reduces EAU induction by inhibiting Th17 autoimmune responses.

Fig. 1

Two groups of B6 mice (n=6) were immunized with IRBP1–20/CFA, then, on day 8 post-immunization, one group was injected i.p. with a single dose of ADA (5U/mouse) and the other with PBS.

(A) A schematic procedure of disease induction and examination

(B) Time-course of the EAU clinical score.

(C) Eye samples from each group were taken on day 25 post-immunization and sections subjected to pathological examination by H&E staining.

(D) Serum was collected on day 13 post-immunization and IL-6, IL-10, IFN-γ, and IL-17 levels measured by ELISA. The data are from a single experiment, representative of three independent experiments **, p < 0.05.