Fig. 4.

Diagram of signaling pathways associated with VM that are affected by CVM-1118. After treating human melanoma cells with CVM-1118, changes in the mRNA, protein expression and phosphorylation of specific members of these different pathways were examined by q-RT-PCR, Western blot analyses, and the R&D Systems Proteome Profiler Antibody Arrays (i.e. Human Apoptosis, Human Phospho-Kinase, Human Phospho-MAPK and Human Cell Stress Arrays).