Table 4.
Impact of race on associations between preoperative lipid levels and risk of prostate cancer recurrence
| Black | Non-black | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| n, total (recurrences) | HR* (95% CI) | p value | n, total (recurrences) | HR* (95% CI) | p value | p-interaction | |
| Total cholesterol | |||||||
| <200 mg/dl | 416 (111) | 1.00 (ref) | 669 (169) | 1.00 (ref) | |||
| 200–239 mg/dl | 165 (52) | 0.95 (0.67–1.34) | 0.763 | 282 (85) | 0.96 (0.73–1.27) | 0.781 | |
| ≥240 mg/dl | 46 (18) | 2.31 (1.39–3.86) | 0.001 | 69 (18) | 1.17 (0.71–1.92) | 0.541 | |
| p-trend=0.063 | p-trend=0.827 | ||||||
| Per 10 mg/dl increase | 628 (181) | 1.06 (1.02–1.11) | 0.006 | 1,020 (272) | 0.99 (0.95–1.03) | 0.557 | 0.011 |
| Per 10 mg/dl increase in men with high cholesterol╪ | 212 (70) | 1.22 (1.13–1.31) | <0.001 | 351 (103) | 0.99 (0.90–1.09) | 0.883 | 0.001 |
|
| |||||||
| LDL | |||||||
| <130 mg/dl | 451 (122) | 1.00 (ref) | 728 (188) | 1.00 (ref) | |||
| 130–159 mg/dl | 130 (48) | 1.19 (0.84–1.67) | 0.331 | 204 (57) | 1.01 (0.74–1.38) | 0.941 | |
| ≥160 mg/dl | 46 (11) | 1.26 (0.67–2.36) | 0.479 | 88 (27) | 1.09 (0.72–1.66) | 0.675 | |
| p-trend=0.263 | p-trend=0.722 | ||||||
| Per 10 mg/dl increase | 628 (181) | 1.04 (0.99–1.10) | 0.079 | 1,020 (272) | 0.98 (0.94–1.02) | 0.331 | 0.028 |
| Per 10 mg/dl increase in men with high LDL╪ | 177 (59) | 1.09 (0.97–1.24) | 0.157 | 292 (84) | 0.96 (0.85–1.08) | 0.479 | 0.051 |
|
| |||||||
| HDL | |||||||
| ≥60 mg/dl | 134 (33) | 1.00 (ref) | 123 (31) | 1.00 (ref) | |||
| 40–59 mg/dl | 305 (85) | 0.85 (0.56–1.31) | 0.467 | 464 (117) | 1.06 (0.69–1.62) | 0.805 | |
| <40 mg/dl | 188 (63) | 0.94 (0.59–1.50) | 0.797 | 433 (124) | 1.31 (0.85–2.01) | 0.226 | |
| p-trend=0.821 | p-trend=0.136 | ||||||
| Per 10 mg/dl increase | 628 (181) | 0.96 (0.87–1.05) | 0.360 | 1,020 (272) | 0.96 (0.88–1.05) | 0.357 | 0.719 |
| Per 10 mg/dl increase in men with low HDL╪ | 188 (63) | 0.40 (0.23–0.70) | 0.001 | 433 (124) | 0.75 (0.51–1.12) | 0.159 | 0.047 |
|
| |||||||
| Triglycerides | |||||||
| <150 mg/dl | 469 (126) | 1.00 (ref) | 660 (174) | 1.00 (ref) | |||
| 150–199 mg/dl | 66 (13) | 0.67 (0.37–1.20) | 0.180 | 178 (41) | 0.86 (0.61–1.23) | 0.415 | |
| ≥200 mg/dl | 92 (42) | 1.75 (1.22–2.52) | 0.003 | 182 (57) | 1.27 (0.94–1.72) | 0.123 | |
| p-trend=0.012 | p-trend=0.218 | ||||||
| Per 10 mg/dl increase | 628 (181) | 1.02 (1.00–1.03) | 0.061 | 1,020 (272) | 1.01 (1.00–1.02) | 0.043 | 0.458 |
| Per 10 mg/dl increase in men with high triglycerides╪ | 158 (55) | 1.02 (0.99–1.05) | 0.268 | 360 (98) | 1.01 (1.00–1.03) | 0.074 | 0.488 |
╪
High lipid levels are defined as ≥200 mg/dl for cholesterol, ≥130 mg/dl for LDL, and ≥150 mg/dl for triglycerides while low HDL levels are defined as <40 mg/dl
*
HRs are adjusted for age, preoperative PSA, year of surgery, BMI, surgical center, postoperative statin use, pathological Gleason score, positive surgical margins, extracapsular extension, and seminal vesicle invasion