Qualitative data eligible for data sets.

Study	Year	Objective defined?	Outcome described?	Characteristics described?	Confounders described?	Main findings outlined?	Heterogeneous population	Strain imaging protocol	Individuals generating data blinded to outcomes	Sonographers blinded to outcome	Reproducibility analysis performed	Case/controls recruited over same time period?
Bussadori et al.7	2008	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	Yes	Yes	Yes
Lorch et al.8	2009	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Pettersen et al.9	2009	Yes	Yes	Yes	Yes	Yes	No	Yes	No	No	Yes	NS
Roberson et al.10	2009	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Cheung et al. 11	2010	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes*	Yes
Koh et al. 12	2010	Yes	Yes	Yes	Yes	Yes	No	Yes	No	No	No	No
Moiduddin et al.13	2010	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	No	No	No
Singh et al.14	2010	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Yu et al.15	2010	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Marcus et al.16	2011	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	Yes	Yes	Yes
Takayasu et al.17	2011	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Blanc et al.18	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	No	Yes	Yes
Di Salvo et al.19	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Fernandes et al.20	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Hirth et al.21	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Koenigstein et al.22	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	No	Yes
Malev et al.23	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Poterucha et al.24	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Sato et al.25	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Takigiku et al.26	2012	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Barbosa et al.27	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Binnetoglu et al.28	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	No	Yes
Dogan et al.29	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	No	Yes
Elkiran et al.30	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes*	NS
Gziri et al.31	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes*	Yes
Hauser et al.32	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	No	Yes
Klitsie et al.33	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
McCandless et al.34	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	No	Yes
Ryan et al.35	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Schubert et al.36	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Sehgal et al.37	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Simsek et al.38	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Van der Ende et al.39	2013	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Black et al.40	2014	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Labombarda et al.41	2014	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Laser et al.42	2014	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Li et al. 43	2014	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	No	Yes	Yes
Mangner et al.44	2014	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Sanchez et al.45	2014	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Vitarelli et al.46	2014	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes
Al-Biltagi et al.47	2015	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes*	Yes
Burkett et al.48	2015	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes
Sainz et al.49	2015	Yes	Yes	Yes	Yes	Yes	No	Yes	NS	NS	Yes	Yes

NR, not recorded; GS_l, Global longitudinal strain; GS_c, Global circumferential strain; GS_r, Global radial strain;

HR, Heart rate; SBP, Systolic blood pressure; BSA, Body surface area

TGA, transposition of the great arteries; LVNC, Left ventricle non-compaction; TOF, Tetralogy of Fallot, FH, Familial hypercholesterolemia; MVP, Mitral valve prolapse;

CAS, Congenital aortic stenosis; LVOTO, Left ventricle outflow tract obstruction; DM, Diabetes mellitus; CHD, Congenital heart disease; DMD, Duchenne Muscular Dystrophy