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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: J Immunol. 2016 Feb 3;196(6):2742–2752. doi: 10.4049/jimmunol.1502331

Fig. 1. NTHi dose-dependently induces inflammation in C57BL/6 mice.

Fig. 1

Mice infected with 1 × 105-107 CFUs NTHi had dose-dependently increased numbers of total cells, neutrophils, and macrophages at 6hrs and 24hrs (A-C) post-infection. NTHi infected mice also had dose-dependent levels of bacteria present in the lung at 6hrs, with >90% of bacteria cleared by 24hrs for all doses (D). NTHi infected mice had prolonged weight loss (E) and prolonged influx of inflammatory cells (F). Statistical significance was determined by one-way ANOVA (overall p=0.0014 [A 6hr], p=0.0041 [A 24hr], p=0.0002 [B 6hr], p=0.0022 [B 24hr], p=0.06 [C 24hr] p<0.0001 [D, E, F]) with Bonferroni’s posttest for multiple comparisons (*p<0.05, **p<0.01, ***p<0.001) n=5 mice/group.