Mice inoculated with AT-RvD1 (20 or 100ng/mouse, OA) and/or NTHi (1 × 106 CFUs, OA) were weighed immediately before infection and at time of sacrifice at 6 and 24hrs (A-B). Additionally, the core temperature was recorded prior to euthanasia at 6 and 24hrs (C-D). Statistical significance was determined by two-way ANOVA (overall p<0.0001 NTHi [A, B, C], p=0.0006 AT-RvD1 [B], p=0.0019 AT-RvD1 [C]) with Bonferroni’s posttest for multiple comparisons (*p<0.05, **p<0.01), n=3-6 mice/group.