Respiratory outcomes were measured for mice inoculated with AT-RvD1 (veh- black bars, 20ng/mouse- dark grey bars, or 100ng/mouse- light grey bars, OA) and/or NTHi (1 × 106 CFUs, OA) at 6 and 24hrs post-infection. Respiratory rates (A, B), tidal volume (C, D) and O2 saturation of hemoglobin (E, F) were assessed. Statistical significance was determined by two-way ANOVA (overall p=0.0044 NTHi [B], p=0.004 NTHi [C], p=0.002 [D], p=0.0005 NTHi [F], p=0.0069 AT-RvD1 [B], p=0.0452 AT-RvD1 [D]) with Bonferroni’s posttest for multiple comparisons (*p<0.05, **p<0.01), n=3-6 mice/group.