Table 2.
Examples for the distribution of macrophages and neutrophils in different types of cancer and autoimmune diseases.
| Type of carcinoma | Localization | Percentage (%) | Mice/human | Ref |
|---|---|---|---|---|
| Macrophages in cancer | ||||
| Mammary gland Gastrointestinal tumors Diffuse large B-cell lymphoma Non-small-cell lung cancer (NSCLC) |
Macrophages are found infiltrating all areas of the tumors (including the perinecroptic areas) Many macrophages are found in the stroma, in close contact with the cancer cells |
>40% <30% 20% 15%–30% |
Mice Human Human Human |
[22] [23] [24] [25, 26] |
| Prostate cancer | In stroma and in close contact with cancer cells | 10%–15% | Human | [27] |
| Pancreatic cancer | Intratumoral and in the invasive front | 30–50% | Human | [28] |
| Colon cancer | Intratumoral, numbers increase with tumor stage and grade | 25%–50% | Human | [29] |
| L929 Fibrosarcoma, B16 melanoma, LLC lung carcinoma cells | Intratumoral | 23–51% | Mice | [30] |
|
| ||||
| Neutrophils in cancer | ||||
| Lung cancer | Infiltrating the tumor | 8% | Human | [31] |
| Clear cell renal cell carcinoma (RCC) | Intratumoral or near vessels | 14% | Human | [32] |
| Mesothelioma, lung cancer | Intratumoral | 0.7–2.5% | Mice | [33] |
| L929 Fibrosarcoma, B16 melanoma, LLC lung carcinoma cells | Intratumoral or near vessels | 3–8% | Mice | [30] |
|
| ||||
| Macrophages in autoimmune diseases | ||||
| Rheumatoid arthritis (RA) | Lining the synovial membrane | 41% | Human | [34] |
| Lining and infiltrating the synovium | 35–46% | Human | [35] | |
| Lining and infiltrating the synovium | 17–36% | Human | [36] | |
| Infiltrating the synovium | 26% | Human | [37] | |
| Multiple sclerosis (MS) | Infiltrating and at the rim of the lesion | 15–30% | Human | [38] |
| Systemic lupus (SLE) | Kidney: infiltrating all parenchyma, found surrounding glomeruli and around perivascular aggregate | 26% | Mice | [39] |
| Systemic lupus (SLE) | Throughout the nephritic kidney | 4% | Mice | [40] |
| Scleroderma | Skin | 23% | Rat | [41] |
| Systemic sclerosis (SSc) | Superficial and deep dermis at early stages | 13% | Human | [42] |
|
| ||||
| Neutrophils in autoimmune diseases | ||||
| Rheumatoid arthritis (RA) | Lining and infiltrating the synovium | 8–15% | Human | [35] |
| Infiltrating the synovium | 4.5–7% | Human | [37] | |
| Experimental autoimmune encephalomyelitis (EAE) | Within brain lesions In the spinal cord |
0.4–3% 8% |
Mice | [43–45] |
| Systemic lupus (SLE, juvenile) | CD15+ low density granulocytes in circulation | 10% | Human | [46] |