Figure 5.

Association between human peripheral blood regulatory T-cells and the IgE response. The frequency of CD4⁺CD25^hi (A) and IL-10⁺ CD4⁺CD25^hi Tregs (B) in PBMCs from 49 infected and 46 uninfected donors was assessed by flow cytometry after 15 h culture with Hp lysate antigen. This was compared to the total plasma IgE concentration for each patient. The data were divided according to whether there were high (>10%) or low frequencies of CD4⁺CD25^hi lymphocytes (C) and high (>0.4%) or low frequencies of IL-10⁺CD4⁺CD25^hi events (D) to further examine associations with total IgE concentrations. NS = no significant difference.