Table 2.
Risk factors of colorectal adenoma in this study population n (%)
| Variable |
Number of persons |
Univariate analysis |
Multivariate analysis1 |
|||
| Non-adenoma | Adenoma | OR (95%CI) | P value | OR (95%CI) | P value | |
| (n = 2264) | (n = 555) | |||||
| Males | 1530 (67.6) | 458 (82.5) | 2.27 (1.79-2.87) | < 0.001 | 1.88 (1.35-2.61) | < 0.001 |
| Age (yr) | ||||||
| ≥ 50 | 741 (32.7) | 302 (54.4) | 1 | < 0.001 | 1 | |
| 45-49 | 386 (17.0) | 105 (18.9) | 0.67 (0.52-0.86) | 0.64 (0.49-0.84) | 0.001 | |
| 40-44 | 504 (22.3) | 87 (15.7) | 0.42 (0.33-0.55) | 0.40 (0.30-0.53) | < 0.001 | |
| < 40 | 633 (28.0) | 61 (11.0) | 0.24 (0.18-0.32) | 0.25 (0.18-0.34) | < 0.001 | |
| Body mass index (kg/m2) | ||||||
| mean ± SD | 23.6 ± 3.2 | 24.4 ± 3.0 | ||||
| < 25 | 1468 (64.8) | 321 (57.8) | 1 | < 0.001 | 1 | |
| 25.0-29.9 | 624 (27.6) | 203 (36.6) | 1.52 (1.25-1.86) | 0.94 (0.72-1.23) | 0.644 | |
| ≥ 30 | 76 (3.4) | 18 (3.2) | 1.11 (0.65-1.88) | 0.68 (0.37-1.24) | 0.204 | |
| Waist circumference (cm) | ||||||
| mean ± SD | 82.6 ± 9.4 | 85.5 ± 8.7 | ||||
| Male < 90, female < 80 | 1658 (73.2) | 353 (63.6) | 1 | < 0.001 | 1 | |
| Male ≥ 90, female ≥ 80 | 606 (6.8) | 202 (36.4) | 1.57 (1.28-1.91) | 1.50 (1.14-1.97) | 0.004 | |
| Diabetes mellitus | 144 (6.4) | 57 (10.3) | 1.69 (1.22-2.33) | 0.001 | 1.12 (0.79-1.57) | 0.533 |
| Hypertension | 623 (27.5) | 229 (41.3) | 1.85 (1.53-2.24) | < 0.001 | 1.27 (0.96-1.67) | 0.095 |
| Metabolic syndrome | 308 (13.6) | 110 (19.8) | 1.57 (1.23-2.00) | < 0.001 | 0.86 (0.59-1.26) | 0.445 |
| hsCRP | ||||||
| < 0.10 | 1 | 0.020 | 1 | |||
| ≥ 0.10 | 1.25 (1.04-1.51) | 1.05 (0.82-1.34) | 0.725 | |||
| Triglyceride (mg/dL) | ||||||
| mean ± SD | 119.7 ± 85.8 | 138.1 ± 91.0 | ||||
| < 150 | 1742 (76.9) | 376 (67.7) | 1 | < 0.001 | 1 | |
| ≥ 150 | 522 (23.1) | 179 (32.3) | 1.59 (1.30-1.95) | 1.15 (0.92-1.45) | 0.227 | |
| HDL cholesterol (mg/dL) | ||||||
| mean ± SD | 57.9 ± 15.0 | 54.9 ± 14.6 | ||||
| Male < 40, female < 50 | 277 (12.2) | 77 (13.9) | 1 | 0.296 | ||
| Male ≥ 40, female ≥ 50 | 1987 (87.8) | 478 (86.1) | 0.87 (0.66-1.14) | |||
| LDL cholesterol (mg/dL) | ||||||
| mean ± SD | 135.7 ± 40.3 | 138.5 ± 36.1 | ||||
| ≤ 100 | 354 (15.6) | 76 (13.7) | 1 | 0.070 | ||
| 101-129 | 699 (30.9) | 152 (27.4) | 1.01 (0.75-1.37) | |||
| ≥ 130 | 1211 (53.5) | 327 (58.9) | 1.26 (0.95-1.66) | |||
| Total cholesterol (mg/dL) | ||||||
| mean ± SD | 206.7 ± 38.5 | 209.0 ± 40.0 | ||||
| < 200 | 1033 (45.6) | 226 (40.7) | 1 | 0.037 | 1 | |
| ≥ 200 | 1231 (54.4) | 329 (59.3) | 1.22 (1.01-1.48) | 1.09 (0.89-1.34) | 0.390 | |
| Current alcohol | 871 (38.5) | 247 (44.5) | 1.28 (1.06-1.55) | 0.009 | 0.93 (0.75-1.16) | 0.513 |
| Smoking status | ||||||
| Never | 994 (43.9) | 160 (28.8) | 1 | < 0.001 | 1 | |
| Former | 584 (25.8) | 18 (33.0) | 1.90 (1.54-2.46) | 1.21 (0.90-1.63) | 0.215 | |
| Current | 68 (30.3) | 21(38.2) | 1.90 (1.53-2.41) | 1.56 (1.16-2.10) | 0.003 | |
1
Adjusted for sex, age, body mass index, waist circumference, diabetes mellitus, hypertension, metabolic syndrome, hsCRP, triglyceride, alcohol, and smoking. hsCRP: High-sensitivity C-reactive protein; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.