Table 3.
Risk factors of colorectal advanced adenoma in this study population n (%)
| Variable |
Number of persons |
Univariate analysis |
Multivariate analysis1 |
|||
| Non-advanced adenoma | Advanced adenoma | OR (95%CI) | P value | OR (95%CI) | P value | |
| (n = 2778) | (n = 41) | |||||
| Males | 1955 (70.4) | 33 (80.5) | 1.74 (0.80-3.78) | 0.159 | 0.80 (0.27-2.43) | 0.697 |
| Age (yr) | ||||||
| ≥ 50 | 1018 (36.6) | 25 (61.0) | 1 | 0.003 | 1 | |
| 45-49 | 485 (17.5) | 6 (14.6) | 0.50 (0.21-1.24) | 0.43 (0.17-1.07) | 0.070 | |
| 40-44 | 587 (21.1) | 4 (9.8) | 0.28 (0.10-0.80) | 0.24 (0.08-0.71) | 0.010 | |
| < 40 | 688 (24.8) | 6 (14.6) | 0.36 (0.15-0.87) | 0.34 (0.13-0.85) | 0.022 | |
| Body mass index (kg/m2) | ||||||
| mean ± SD | 23.7 ± 3.1 | 24.5 ± 3.0 | ||||
| < 25 | 1764 (63.5) | 25 (61.0) | 1 | 0.518 | ||
| 25.0-29.9 | 814 (29.3) | 13 (31.7) | 1.15 (0.59-2.25) | |||
| ≥ 30 | 92 (3.3) | 2 (4.9) | 1.57 (0.37-6.70) | |||
| Waist circumference (cm) | ||||||
| mean ± SD | 83.1 ± 9.4 | 85.9 ± 7.1 | ||||
| Male < 90, female < 80 | 1985 (71.5) | 26 (63.4) | 1 | 0.258 | ||
| Male ≥ 90, female ≥ 80 | 793 (28.5) | 15 (36.6) | 1.44 (0.76-2.74) | |||
| Diabetes mellitus | 196 (7.1) | 5 (12.2) | 1.83 (0.71-4.72) | 0.204 | ||
| Hypertension | 835 (30.1) | 17 (41.5) | 1.65 (0.88-3.08) | 0.114 | 1.03 (0.45-2.38) | 0.947 |
| Metabolic syndrome | 409 (14.7) | 9 (22.0) | 1.63 (0.77-3.44) | 0.196 | 1.06 (0.40-2.80) | 0.907 |
| hsCRP (mg/dL) | ||||||
| < 0.10 | 1747 (62.9) | 24 (58.5) | 1 | 0.567 | ||
| ≥ 0.10 | 1031 (37.1) | 17 (41.5) | 1.20 (0.64-2.25) | |||
| Triglyceride (mg/dL) | ||||||
| mean ± SD | 123.1 ± 87.3 | 136.8 ± 75.3 | ||||
| < 150 | 2091 (75.3) | 27 (65.9) | 1 | 0.166 | 1 | |
| ≥ 150 | 687 (24.7) | 14 (34.1) | 1.58 (0.82-3.03) | 1.23 (0.62-2.45) | 0.555 | |
| HDL cholesterol (mg/dL) | ||||||
| mean ± SD | 57.3 ± 15.0 | 56.2 ± 15.7 | ||||
| Male < 40, female < 50 | 348 (12.5) | 6 (14.6) | 1 | 0.686 | ||
| Male ≥ 40, female ≥ 50 | 2430 (87.5) | 35 (85.4) | 0.84 (0.35-2.00) | |||
| LDL cholesterol (mg/dL) | ||||||
| mean ± SD | 136.3 ± 39.4 | 137.2 ± 46.3 | ||||
| ≤ 100 | 423 (15.2) | 7 (17.1) | 1 | 0.876 | ||
| 101-129 | 840 (30.2) | 11 (26.8) | 0.79 (0.31-2.06) | |||
| ≥ 130 | 1515 (54.5) | 23 (56.1) | 0.92 (0.39-2.15) | |||
| Total cholesterol (mg/dL) | ||||||
| mean ± SD | 207.1 ± 38.5 | 208.7 ± 52.1 | ||||
| < 200 | 1240 (44.6) | 19 (46.3) | 1 | 0.827 | ||
| ≥ 200 | 1538 (55.4) | 22 (53.7) | 0.93 (0.50-1.73) | |||
| Current alcohol | 1093 (39.3) | 25 (61.0) | 2.41 (1.28-4.53) | 0.005 | 2.39 (1.14-4.99) | 0.021 |
| Smoking status | ||||||
| Never | 1143 (41.1) | 11 (26.8) | 1 | 0.106 | 1 | |
| Former | 753 (27.1) | 14 (34.1) | 1.93 (0.87-4.28) | 1.40 (0.50-3.92) | 0.516 | |
| Current | 882 (31.7) | 16 (39.0) | 1.89 (0.87-4.08) | 1.61 (0.58-4.45) | 0.363 | |
1
Adjusted for sex, age, hypertension, metabolic syndrome, triglyceride, alcohol, and smoking. hsCRP: High-sensitivity C-reactive protein; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.