Table 4.
Risk factors for colorectal adenoma in young subjects n (%)
| Variable |
Number of persons |
Univariate analysis |
Multivariate analysis1 |
|||
| Non-adenoma | Adenoma | OR (95%CI) | P value | OR (95%CI) | P value | |
| (n = 1523) | (n = 253) | |||||
| Males | 1060 (69.6) | 211 (83.4) | 2.19 (1.55-3.11) | < 0.001 | 1.43 (0.89-2.28) | 0.136 |
| Age (yr) | ||||||
| 45-49 | 386 (25.3) | 105 (41.5) | 1 | < 0.001 | 1 | |
| 40-44 | 504 (33.1) | 87 (34.4) | 0.64 (0.46-0.87) | 0.64 (0.46-0.88) | 0.006 | |
| < 40 | 633 (41.6) | 61 (24.1) | 0.35 (0.25-0.50) | 0.39 (0.28-0.56) | < 0.001 | |
| Body mass index (kg/m2) | ||||||
| mean ± SD | 23.5 ± 3.2 | 24.4 ± 3.1 | ||||
| 18.5-24.9 | 993 (65.2) | 144 (56.9) | 1 | 0.002 | 1 | |
| 25.0-29.9 | 402 (26.4) | 94 (37.2) | 1.66 (1.25-2.20) | 0.90 (0.61-1.33) | 0.599 | |
| ≥ 30 | 55 (3.6) | 9 (3.6) | 1.16 (0.56-2.40) | 0.55 (0.24-1.27) | 0.161 | |
| Waist circumference (cm) | ||||||
| mean ± SD | 82.1 ± 9.7 | 85.2 ± 9.3 | ||||
| Male < 90, female < 80 | 1161 (76.2) | 164 (64.8) | < 0.001 | 1 | ||
| Male ≥ 90, female ≥ 80 | 362 (23.8) | 89 (35.2) | 1.74 (1.31-2.31) | 1.72 (1.15-2.55) | 0.008 | |
| Diabetes mellitus | 55 (3.6) | 16 (6.3) | 1.80 (1.02-3.20) | 0.041 | 1.29 (0.71-2.35) | 0.403 |
| Hypertension | 309 (20.3) | 81 (32.0) | 1.85 (1.38-2.48) | < 0.001 | 1.36 (0.92-2.02) | 0.127 |
| Metabolic syndrome | 154 (10.1) | 38 (15.0) | 1.57 (1.07-2.30) | 0.020 | 0.88 (0.53-1.46) | 0.612 |
| hsCRP (mg/dL) | 128 (8.4) | 22 (8.7) | ||||
| < 0.10 | 1004 (65.9) | 156 (61.7) | 1 | 0.187 | ||
| ≥ 0.10 | 519 (34.1) | 97 (38.3) | 1.20 (0.91-1.58) | |||
| Triglyceride (mg/dL) | ||||||
| mean ± SD | 119.2 ± 86.4 | 146.2 ± 101.3 | ||||
| < 150 | 1168 (76.7) | 165 (65.2) | 1 | < 0.001 | 1 | |
| ≥ 150 | 355 (23.3) | 88 (34.8) | 1.76 (1.32-2.33) | 1.18 (0.85-1.63) | 0.330 | |
| HDL cholesterol (mg/dL) | ||||||
| mean ± SD | 58.0 ± 14.8 | 55.4 ± 15.4 | ||||
| Male < 40, female < 50 | 162 (10.6) | 30 (11.9) | 1 | 0.563 | ||
| Male ≥ 40, female ≥ 50 | 1361 (89.4) | 223 (88.1) | 0.89 (0.59-1.34) | |||
| LDL cholesterol (mg/dL) | ||||||
| mean ± SD | 135.1 ± 43.0 | 138.7 ± 36.8 | ||||
| ≤ 100 | 244 (16.0) | 38 (15.0) | 1 | 0.106 | ||
| 101-129 | 493 (32.4) | 67 (26.5) | 0.87 (0.57-1.34) | |||
| ≥ 130 | 786 (51.6) | 148 (58.5) | 1.21 (0.82-1.78) | |||
| Total cholesterol (mg/dL) | ||||||
| mean ± SD | 205.8 ± 38.1 | 210.9 ± 39.6 | ||||
| < 200 | 715 (46.9) | 100 (39.5) | 1 | 0.028 | 1 | |
| ≥ 200 | 808 (53.1) | 153 (60.5) | 1.35 (1.03-1.78) | 1.08 (0.81-1.44) | 0.595 | |
| Current alcohol | 637 (41.8) | 133 (52.6) | 1.54 (1.18-2.01) | 0.001 | 1.04 (0.77-1.40) | 0.806 |
| Smoking status | ||||||
| Never | 639 (42.0) | 66 (26.1) | 1 | < 0001 | 1 | |
| Former | 339 (22.3) | 62 (24.5) | 1.77 (1.22-2.57) | 1.23 (0.79 -1.93) | 0.359 | |
| Current | 545 (35.8) | 125 (49.4) | 2.22 (1.61-3.06) | 1.60 (1.07-2.41) | 0.023 | |
1
Adjusted for sex, age, body mass index, waist circumference, diabetes mellitus, hypertension, metabolic syndrome, triglyceride, total cholesterol, alcohol, and smoking. hsCRP: High-sensitivity C-reactive protein; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.