Table 5.
Risk factors of colorectal advanced adenoma in young subjects n (%)
| Variable |
Number of persons |
Univariate analysis |
Multivariate analysis1 |
|||
| Non-advanced adenoma | Advanced adenoma | OR (95%CI) | P value | OR (95%CI) | P value | |
| (n = 1760) | (n = 16) | |||||
| Males | 1258 (71.5) | 13 (81.3) | 1.73 (0.49-6.09) | 0.388 | ||
| Age (yr) | ||||||
| 45-49 | 485 (27.6) | 6 (37.5) | 1 | 0.570 | ||
| 40-44 | 587 (33.4) | 4 (25.0) | 0.55 (0.16-1.96) | |||
| < 40 | 688 (39.1) | 6 (37.5) | 0.71 (0.23-2.20) | |||
| Body mass index (kg/m2) | ||||||
| mean ± SD | 23.6 ± 3.2 | 24.8 ± 2.8 | ||||
| < 25 | 79 (4.5) | 0 (0.0) | 1 | 0.862 | ||
| 25.0-29.9 | 492 (28.0) | 4 (25.0) | 1.66 (1.25-2.20) | |||
| ≥ 30 | 63 (3.6) | 1 (6.3) | 1.16 (0.56-2.40) | |||
| Waist circumference (cm) | ||||||
| mean ± SD | 82.5 ± 9.7 | 86.1 ± 6.6 | ||||
| Male < 90, female < 80 | 1313 (74.6) | 12 (75.0) | 1 | 0.971 | ||
| Male ≥ 90, female ≥ 80 | 447 (25.4) | 4 (25.0) | 0.98 (0.31-3.05) | |||
| Diabetes mellitus | 70 (4.0) | 1 (6.3) | 1.61 (0.21-12.36) | 0.644 | ||
| Hypertension | 388 (22.0) | 2 (12.5) | 0.51 (0.11-2.23) | 0.359 | ||
| Metabolic syndrome | 191 (10.9) | 1 (6.3) | 0.55 (0.07-4.17) | 0.555 | ||
| High hsCRP | ||||||
| mean ± SD | 148 (8.4) | 2 (12.5) | ||||
| < 0.10 | 1149 (65.3) | 11 (68.8) | 1 | 0.772 | ||
| ≥ 0.10 | 611 (34.7) | 5 (31.3) | 0.86 (0.30-2.47) | |||
| Triglyceride (mg/dL) | ||||||
| mean ± SD | 123.0 ± 89.3 | 121.1 ± 72.3 | ||||
| < 150 | 1321 (75.1) | 12 (75.0) | 1 | 0.996 | ||
| ≥ 150 | 439 (24.9) | 4 (25.0) | 1.00 (0.32-3.13) | |||
| HDL cholesterol (mg/dL) | ||||||
| mean ± SD | 57.6 ± 14.8 | 60.1 ± 19.3 | ||||
| Male < 40, female < 50 | 191 (10.9) | 1 (6.3) | 1 | 0.555 | ||
| Male ≥ 40, female ≥ 50 | 1569 (89.1) | 15 (93.8) | 1.83 (0.24-13.90) | |||
| LDL cholesterol (mg/dL) | ||||||
| mean ± SD | 135.5 ± 41.9 | 139.1 ± 43.9 | ||||
| ≤ 100 | 278 (15.8) | 4 (25.0) | 1 | 0.703 | ||
| 101-129 | 559 (31.8) | 1 (6.3) | 0.12 (0.01-1.12) | |||
| ≥ 130 | 923 (52.4) | 11 (68.8) | 0.83 (0.26-2.62) | |||
| Total cholesterol (mg/dL) | ||||||
| mean ± SD | 206.4 ± 38.3 | 214.1 ± 41.3 | ||||
| < 200 | 810 (46.0) | 5 (31.3) | 1 | 0.238 | ||
| ≥ 200 | 950 (54.0) | 11 (68.8) | 1.88 (0.65-5.42) | |||
| Current alcohol | 758 (43.1) | 12 (75.0) | 3.97 (1.27-12.34) | 0.010 | 3.69 (1.08-12.54) | 0.037 |
| Smoking status | ||||||
| Never | 701 (39.8) | 4 (25.0) | 1 | 0.129 | 1 | |
| Former | 398 (22.6) | 3 (18.8) | 1.32 (0.29-5.93) | 0.81 (0.17-3.86) | 0.789 | |
| Current | 661 (37.6) | 9 (56.3) | 2.39 (0.73-7.79) | 1.38 (0.39-4.93) | 0.620 | |
1
Adjusted for alcohol and smoking. hsCRP: High-sensitivity C-reactive protein; HDL: High-density lipoprotein cholesterol; LDL: Low-density lipoprotein cholesterol.