Table 2.
Subgroup meta-analysis for the correlation between hepatitis B virus infection and overall survival
| Subgroup | n | Analytical model | HR | 95%CI |
Heterogeneity |
|
| I2 (%) | P value | |||||
| Sample size | ||||||
| Sample size ≥ 100 | 5 | FEM | 0.72 | 0.65-0.81 | 33.3 | 0.200 |
| Sample size < 100 | 6 | FEM | 0.84 | 0.72-0.98 | 28.7 | 0.219 |
| Tumor type | ||||||
| MF, PI or IG | 8 | REM | 0.75 | 0.62-0.90 | 51.8 | 0.043 |
| MF only | 3 | FEM | 0.74 | 0.64-0.85 | 0.00 | 0.709 |
| Study region | ||||||
| China | 8 | FEM | 0.75 | 0.69-0.82 | 40.7 | 0.107 |
| Non-China | 3 | FEM | 1.10 | 0.67-1.80 | 0.00 | 0.476 |
| Mean age | ||||||
| Mean age ≥ 55 | 8 | FEM | 0.71 | 0.62-0.82 | 37.6 | 0.130 |
| Mean age < 55 | 2 | REM | 0.80 | 0.67-0.95 | 59.7 | 0.115 |
FEM: Fixed-effects model; REM: Random-effects model; HR: Hazard ration; CI: Confidence interval; MF: Mass-forming; PI: Periductal infiltrating; IG: Intraductal growth.