Table 3.
Effect of Panax quinquefolius (GIN) and its interaction with GABA modulators on locomotor activity in 72-h sleep deprived animals.
| S. No. | Treatment group (mg/kg) | Total activity day 8 (Counts/5 min) |
|---|---|---|
| 1 | Naïve | 204.00, 2.75 |
| 2 | Control (SD-72 h) | 63.428, 5.68a |
| 3 | GIN (50) | 71.66, 6.36a |
| 4 | GIN (100) | 119.875, 8.87b,c |
| 5 | GIN (200) | 135.67, 5.62b,c |
| 6 | PTX (0.5) | 64.42, 5.50a |
| 7 | PTX (0.5) + GIN (100) | 78.0, 2.65a,d |
| 8 | FLU (0.5) | 66.21, 3.41a |
| 9 | FLU (0.5) + GIN (100) | 81.33, 4.11a,d |
| 10 | MUS (0.05) | 70.60, 4.61a |
| 11 | MUS (0.05) + GIN (100) | 195.21, 3.97b,d,e |
Values are expressed as mean ± SEM.
a
p < 0.05 as compared with naive,
b
p < 0.05 as compared with control (SD-72),
c
p < 0.05 as compared with GIN (50 mg/kg),
d
p < 0.05 as compared with GIN (100 mg/kg),
e
p < 0.05 as compared with MUS (0.05 mg/kg).
(One-way ANOVA followed by Tukey's test). SD-72, Sleep deprivation of 72-h; GIN, Panax quinquefolius (American ginseng); PTX, Picrotoxin; FLU, Flumazenil; MUS, Muscimol.