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. 2016 Mar 7;7:58. doi: 10.3389/fphys.2016.00058

Figure 2.

Figure 2

Tissue-engineering strategies for regenerative endodontics through a cell homing strategy. Step 1. Root canal disinfection and enlargement of apical foramen. Step 2. Bioactive scaffold transplantation and tooth restoration. Load bioactive scaffold in the canal after cleaning the antibiotics effectively. The growth factors, which are released from the scaffold to the surrounding tissues, will recruit cells into the scaffold. Step 3. Pulp-formation process. Recruited cells migrate, proliferate, differentiate in the scaffold, and participate in the formation of blood vessels, nerves, and regulated dentin deposition. During this step, regular follow-up to check the viability of the regenerated pulp are needed.