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. Author manuscript; available in PMC: 2017 Jan 14.
Published in final edited form as: J Med Chem. 2015 Dec 30;59(1):219–237. doi: 10.1021/acs.jmedchem.5b01276

Figure 4.

Figure 4

Partial agonist activity of three ShERPAs (30a, 23 and 30b) assessed by activation of ERE (estrogen response element) in MCF-7:ws8 cells (normalized to 0.1 nM E2 = 100%) using a luciferase assay after treatment for 18h. The antagonist action of these ShERPAs was assessed in the presence of 0.1 nM E2 and a dose dependent reduction in E2 luciferase activity is seen with increasing concentrations of ShERPAs (100-500 nM). Data show mean and s.e.m from at least three cell passages.