. Author manuscript; available in PMC: 2017 Jan 14.

Published in final edited form as: J Med Chem. 2015 Dec 30;59(1):219–237. doi: 10.1021/acs.jmedchem.5b01276

Table 2.

Relative binding affinity of selected ShERPAs in radioligand displacement assay

Compounds	RBA^a
E₂	100
26a	1.3 ± 0.3
23	7.9 ± 0.3
30a	92.4 ± 21

Relative binding affinity (RBA) values, determined by radiometric assays, are expressed as IC₅₀ estradiol/IC₅₀ compound × 100 ± the range or standard deviation (RBA, estradiol = 100%).