Table 2.
Details of the Drug Resistance Mutations Present in Study Participants
| Mutations | Number of patients (%) | Mutation classification | Association with resistance to protease inhibitors |
|---|---|---|---|
| L33I | 14 (22) | *+Minor/Nonpolymorphic | *ATV/RTV |
| T74S | 1 (2) | *+Minor/Polymorphic | +NFV |
| A71T | 1 (2) | *+Minor/Polymorphic | *ATV/RTV/IDV/LPV/NFV/SQV |
| K43T | 1 (2) | *+Minor/Nonpolymorphic | *TPV |
| R41K | 55 (87) | +Other/Polymorphic | None |
| M36I | 50 (79) | +Other or *Minor/Polymorphic | *ATV/RTV/IDV/NFV/TPV |
| H69K | 45 (71) | +Other or *Minor/Polymorphic | *TPV/RTV |
| L89M | 43 (68) | +Other or *Minor/Polymorphic | *TPV/RTV |
| E35D | 28 (44) | +Other/Polymorphic | None |
| L63A | 13 (21) | +Other/Polymorphic | None |
| L63P | 13 (21) | +Other or *Minor/Polymorphic | *LPV/RTV |
| I64V | 11 (17) | +Other or *Minor/Polymorphic | *ATV/RTV |
| V77I | 10 (16) | +Other or *Minor/Polymorphic | *IDV/RTV/NFV/SQV |
| I62V | 7 (11) | +Other or *Minor/Polymorphic | *ATV/RTV/SQV |
| I93L | 7 (11) | +Other or *Minor/Polymorphic | *ATV/RTV |
| V82I | 4 (6) | +Other or *Minor/Highly polymorphic | *ATV/RTV |
| L89I | 3 (5) | +Other or *Minor/Polymorphic | *TPV/RTV |
| L33V | 2 (3) | +Other or *Minor/Polymorphic | *ATV/RTV |
| H69R | 2 (3) | +Other or *Minor/Polymorphic | *TPV/RTV |
| I64L | 2 (3) | +Other or *Minor/Polymorphic | *ATV/RTV |
| E34Q | 1 (2) | +Other or *Minor/Polymorphic | *ATV/RTV |
The table presents the prevalence of different drug resistance mutations observed in the study participants. In the mutation classification column, + indicates mutations that are classified as minor or other drug resistance mutations by the Stanford drug resistance database, while * indicates mutations that are classified as minor drug resistance mutations by the International AIDS Society.15 In the association with resistance to protease inhibitors column, + shows the association of a mutation with resistance to a particular drug, as indicated in the Stanford drug resistance database, while * shows the association of a mutation with a particular drug, as indicated by the International AIDS Society.15 The abbreviations of the antiretroviral drugs are as follows: atazanavir (ATV), ritonavir (RTV), nelfinavir (NFV), indinavir (IDV), lopinavir (LPV), saquinavir (SQV), and tipranavir (TPV).