Table 3. Cox multivariate proportional hazard model of independent predictors on disease-free and overall survival.

Variable	Hazard ratio (95% CI)	P value
Disease-free survival
Gender (male vs female)	1.426 (0.809–2.513)	0.220
Tumor size, cm (≥5 vs <5)	3.085 (1.690–5.630)	<0.001
Tumor number (multiple vs single)	1.048 (0.666–1.649)	0.840
TNM stage (III–IV vs I–II)	1.231 (0.760–1.993)	0.399
PVTT (yes vs no)	2.125 (1.071–4.021)	0.032
AKR1B10 expression (high vs low)	1.965 (1.187–3.256)	0.009
Overall survival
Gender (male vs female)	1.383 (0.784–2.440)	0.263
Tumor size, cm (≥5 vs<5)	2.727 (1.478–5.034)	0.001
Tumor number (multiple vs single)	0.987 (0.629–1.549)	0.954
TNM stage (III–IV vs I–II)	1.321 (0.815–2.141)	0.259
PVTT (yes vs no)	2.015 (1.058–3.985)	0.035
Recurrence (yes vs no)	1.776 (1.105–2.853)	0.018
AKR1B10 expression (high vs low)	1.866 (1.127–3.091)	0.015

CI, confidence interval; TNM, tumor-node-metastasis; PVTT, portal vein tumor thrombus.