Table 2. Characteristics of patients with ophtalmic beta-blocker-induced conduction defects.

Patient’s age/gender	Drug type	Therapy duration (months)	Conduction defect	Temporary/permanent pacemeker
81/M	Betaxolol	24	3rd-degree AV block	Yes/Yes
58/F	Timolol	40	Sinus pause	No/Yes
78/F	Timolol	52	3rd-degree AV block	Yes/No*
82/M	Timolol	14	High-degree AV block	No/Yes
85/M	Timolol	15	3rd-degree AV block	No/Yes
62/F	Timolol	61	Sinus pause	No/No*
56/F	Timolol	44	3rd-degree AV block	No/Yes
62/M	Cartelol	32	High-degree AV block	No/Yes**
73/M	Betaxolol	16	3rd-degree AV block	No/Yes
83/F	Betaxolol	18	High-degree AV block	No/Yes
72/M	Cartelol	11	3rd-degree AV block	Yes/Yes
65/F	Betaxolol	37	High-degree AV block	No/Yes
76/M	Timolol	27	3rd-degree AV block	No/Yes

*Rhythm was improved and conduction disturbance never recurred after drug withdrawal; **Rhythm was improved but recurred one month after drug discontinuation. AV: atrioventricular.