Table 2.

The key components of the systematic review described using the standard PICOS (Participants, Interventions, Comparisons, Outcomes and Study design) formula

Participants	People with type 2 diabetes who required treatment with one or more medications
Interventions	Glucose-lowering medications
Comparisons	Other classes of glucose-lowering medications (metformin to be used as the default comparator where available)
Outcomes	Any reported measure of patient adherence or persistence with treatment
Study design	Both interventional and observational studies