Figure 5. Various types of axonal degeneration and myelin sheath abnormalities detected by electron microscopy in the ventral root of the cervical 5 segment post-MCAO in hypertensive rats.

(A) A normal axon with an intact myelin sheath. (B) A shrunken axon surrounded by debris from the myelin sheath. (C) A degenerated axon without a microfilament and microtubules. (D,E) Axoplasmic accumulation of dystrophic membranous debris with different profiles. (F) Swollen mitochondria in the axon. (G) Peri-axonal swelling. (H) A degenerated axon with loose myelin sheath lamellae. (I) Infolding of the myelin sheath. Panel A was examined at 1 week after sham operation. Panels (B–H) were observed at W1, and panel I was detected at W12 post-MCAO.