Figure 4. Sequence analysis of TM translocation peptide candidates from the top positive phage clones.

(A) Phylogenetic tree analysis grouping the different peptide sequences by similarity. Comparison of these six peptides primary sequence reveals the structural similarities in the side chains. The color schematics are same as in Fig. 1. (B,C) Consensus Logo plot contour of the two families of peptides that target TM showing the core motifs identified for group 1: “ST(K/R)T” and group 2: “PxxP”.