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. 2016 Feb 5;7(5):500–511. doi: 10.7150/jca.13599

Table 2.

Synergistic effect of Erlotinib and GLE in SUM-149 cells.

Combination Index
Constant Ratio
Treatment ED50 ED75 ED90 ED95 Dm
Erl+GLE 0.60914 0.54950 0.49573 0.46221 0.10815
Erl (μM) 0.59348
GLE (mg/mL) 0.17742
Non-constant Ratio
Dose Erl (μM) Dose GLE (mg/mL) Effect CI Description
0.06 0.05 0.23473 1.99448 A
0.13 0.43761 0.64429 S
0.25 0.48714 0.76154 MS
0.50 0.52588 0.94897 SlS
1.00 0.57428 1.18357 SlA
2.00 0.65307 1.21960 MA
4.00 0.67108 2.00307 A

Dm means the median effect dose or the potency of each drug such as IC50, ED50. A=Antagonism, MA=Moderate Antagonism, MS=Moderate Synergism, S=Synergism, SlA=Slight Antagonism, SlS=Slight Synergism.