Table 3.

EE results and analysis of orthogonal experiment of the preparation of NRG-SLNs

No	A	B	C	D	EE%
1	1	1	1	1	40.68
2	1	2	2	2	56.50
3	1	3	3	3	67.73
4	2	1	2	3	65.80
5	2	2	3	1	59.57
6	2	3	1	2	53.14
7	3	1	3	2	78.22
8	3	2	1	3	66.11
9	3	3	2	1	60.41
$\overline{K}1$	54.970	61.567	53.310	53.553	–
$\overline{K}2$	59.503	60.727	60.903	62.620	–
$\overline{K}3$	68.247	60.427	68.507	66.547	–
R	13.277	1.140	15.197	12.994	–

Notes: Factor A, emulsifying temperature; factor B, the volume ratio of the oil phase to the inner water phase; factor C, the mass ratio of drug to lipids; and factor D, the mass ratio of F68 to T80. EE was expressed as mean (n=3).

Abbreviations: NRG, naringenin; SLNs, solid lipid nanoparticles; EE, encapsulation efficiency.