Table 10.
Dose (ppm) | Liver weights | Days on study | |||||
---|---|---|---|---|---|---|---|
| |||||||
1 | 2 | 3 | 7 | 14 | 28 | ||
50 | Absolute | 109 (5) | 107 (5) | 106 (5) | 112 (5)* | 126 (5)* | 112 (5)** |
Relative | 108 (5)** | 107 (5) | 107 (5)* | 111 (5)* | 121 (5)** | 110 (5)** | |
160 | Absolute | 105 (5) | 114 (5) | 121 (5)** | 127 (5)** | 142 (5)** | 124 (5)** |
Relative | 107 (5)* | 113 (5)** | 119 (5)** | 123 (5)** | 136 (5)** | 122 (5)** | |
500 | Absolute | 110 (5) | 125 (5)** | 127 (5)** | 153 (5)** | 148 (5)** | 142 (5)** |
Relative | 111 (5)** | 125 (5)** | 129 (5)** | 147 (5)** | 148 (5)** | 145 (5)** |
Values represent percentages (%) to control values.
(n): Number of animals examined.
Relative: Ratio to body weight (%)
Significantly different from control at p < 0.05 and p < 0.01, respectively (Dunnett’s multiple comparison test).