Table 18.
Microarray assay of hepatoproliferative lesions in male F344 rats from a 2-year feeding study of p,p′-DDT
| Gene/protein name | Function | Fold change (ratio to normal control value)* | |||
|---|---|---|---|---|---|
|
| |||||
| Hypertorophy | Eosinophilic AHF | Adenoma | |||
|
|
|
|
|||
| 500 ppm | 0 ppm | 500 ppm | 500 ppm | ||
| Protein kinase C-eta | Cell proliferation (CP) | 3.6 | 3.2 | 3.1 | 2.5 |
| Uncouplingprotein 2, mitochondrial | CP | 2.0 | - | 2.0 | - |
| Phosphorylase B kinase catalytic subunit | CP | - | - | 2.2 | - |
| Guanine nucleotide-binding protein G-s, α subunit | CP | 2.5 | - | 2.6 | 2.3 |
| G protein γ-5 subunit | CP | 2.0 | - | 3.5 | - |
| CDK106 | CP (Downerg. TGF-β) | - | - | 2.0 | 2.0 |
| Follistatin | CP (Downerg. TGF-β) | - | - | 0.5 | - |
| Lipoprotein lipase | CP (TGF-β) | - | - | 0.5 | - |
| Ubiquitin-conjugating enzyme E2D3 | CP (Cell cycle) | - | - | 0.5 | - |
| p53-activated gene 608 | Apoptosis (Apo) | - | - | 2.3 | 2.0 |
| Sodium channel β2 | Apo (suppre) | 2.9 | 2.2 | 3.2 | 2.4 |
| Protein disulfide isomerase A6 precursor | Apo (suppre) | - | - | 0.5 | - |
| Protein phosphatase type 1α, catalytic subunit | Apo (suppre) | 0.5 | - | 0.4 | - |
| Potassium channel gene 1 (Kir6) | Anti-oxidative | 3.2 | 2.7 | 3.1 | 2.5 |
| Dopamine receptor D2 | Anti-oxidative | 2.7 | 3.0 | 2.1 | 2.2 |
*
Values of 2.0 or more and 0.5 or less represent up-regulation and down-regulation, respectively.
–: Within normal range.