Table 6.
PCNA LI (%) in the liver of male F344 rats from a 4-week feeding study of p,p′-DDT
| Dose (ppm) | PCNA LI (mean ± SD) on days | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| 1 | 2 | 3 | 7 | 14 | 28 | |||||||
| 0 | 2.00 ± 0.80 | (5) | 1.58 ± 0.68 | (5) | 3.19 ± 1.44 | (5) | 4.46 ± 1.41 | (5) | 1.75 ± 0.77 | (5) | 0.96 ± 0.50 | (5) |
| 50 | 2.06 ± 0.46 | (5) | 3.22 ± 0.51* | (5) | 4.84 ± 1.60 | (5) | 5.37 ± 0.36 | (5) | 0.96 ± 0.31 | (5) | 0.58 ± 0.18 | (5) |
| 160 | 2.81 ± 0.67 | (5) | 5.91 ± 1.49** | (5) | 6.85 ± 1.71** | (5) | 4.13 ± 0.72 | (5) | 0.62 ± 0.54 | (5) | 0.60 ± 0.34 | (5) |
| 500 | 4.62 ± 1.01** | (5) | 5.33 ± 0.59** | (5) | 6.31 ± 1.57* | (5) | 4.52 ± 1.27 | (5) | 1.39 ± 1.19 | (5) | 0.94 ± 0.48 | (5) |
(n): Number of animals examined.
*, **
Significantly different from control at p < 0.05 and p < 0.01, respectively (Dunnett’s multiple comparison test).