Table 8.
Number of GJIC protein Cx32 spots in the liver of male F344 rats from a 4-week feeding study of p,p′-DDT
| Dose (ppm) | No. of Cx32 spots (mean ± SD) on days: | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| 1 | 2 | 3 | 7 | 14 | 28 | |||||||
| 0 | 8.29 ± 0.36 | (5) | 7.81 ± 0.75 | (5) | 7.86 ± 0.81 | (5) | 7.24 ± 0.38 | (5) | 7.64 ± 0.52 | (5) | 8.11 ± 0.22 | (5) |
| 50 | 5.59 ± 0.77** | (5) | 4.69 ± 0.33** | (5) | 5.41 ± 0.40** | (5) | 3.14 ± 0.33** | (5) | 2.99 ± 0.53** | (5) | 3.33 ± 0.74** | (5) |
| 160 | 4.90 ± 0.63** | (5) | 4.37 ± 0.64** | (5) | 3.94 ± 0.64** | (5) | 3.06 ± 0.46** | (5) | 2.71 ± 0.68** | (5) | 2.77 ± 0.43** | (5) |
| 500 | 5.35 ± 1.03** | (5) | 3.98 ± 0.41** | (5) | 3.12 ± 0.33** | (5) | 2.62 ± 0.70** | (5) | 1.75 ± 0.51** | (5) | 1.68 ± 0.79** | (5) |
(n): Number of animals examined.
**
Significantly different from control at p < 0.01 (Dunnett’s multiple comparison test).